ml-210

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	50mg
Item no.	V25664-50mg
CASRN	1360705-96-9
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V25664CAS #:1360705-96-9Purity >=98% Description: ML-210 (CID 49766530) is a novel, potent, selective RAS inhibitor, also a potent and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity. ML-210 displayed nanomolar potency in the primary screening cell line while maintaining selectivity similar to previously identified probes. The probe is in a novel structural class in the field of RAS synthetically lethal compounds and will, therefore, be highly useful in identifying pathways that can potentially be used for selectively inhibiting cancer cells. 10 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity References: 1. John K. Eaton, et al. Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors. Biorxiv. 2018. 2. Weïwer M, et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012 Feb 15; 22(4):1822-6.

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Amount: 50mg

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Delivery expected until 6/6/2024