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Description: Telotristat (formerly known as LP-778902) is the active metabolite of LX1606 (Telotristat etiprate) which is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential an in vivo IC50 of 0.028 uM and with antiserotonergic activity. Telotristat has activity in controlling diarrhea associated with carcinoid syndrome. Telotristat acts by inhibiting the enzyme tryptophan hydoxylase (TPH) and reduces serotonin production both inside and outside the GI tract without affecting brain serotonin levels. Blocking peripheral serotonin synthesis by telotristat reduces severity of both chemical- and infection-induced intestinal inflammation.
References: Gut. 2014 Jun; 63(6):928-37.
Related CAS#: 1137608-69-5 (Telotristat etiprate); 1033805-22-9 (Telotristat ethyl); 1374745-52-4 (Telotristat besilate); 1033805-28-5 (free acid)
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