Comparison

telotristat

Item no. V2614-5mg
Manufacturer InvivoChem LLC
CASRN 1033805-28-5
Amount 5mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias 1033805-28-5
Available
Description
InvivoChem Cat #:V2614CAS #:1033805-28-5 Purity >=98%

Description: Telotristat (formerly known as LP-778902) is the active metabolite of LX1606 (Telotristat etiprate) which is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential an in vivo IC50 of 0.028 uM and with antiserotonergic activity. Telotristat has activity in controlling diarrhea associated with carcinoid syndrome. Telotristat acts by inhibiting the enzyme tryptophan hydoxylase (TPH) and reduces serotonin production both inside and outside the GI tract without affecting brain serotonin levels. Blocking peripheral serotonin synthesis by telotristat reduces severity of both chemical- and infection-induced intestinal inflammation.

Description:

References: Gut. 2014 Jun; 63(6):928-37.

References:

Related CAS#: 1137608-69-5 (Telotristat etiprate); 1033805-22-9 (Telotristat ethyl); 1374745-52-4 (Telotristat besilate); 1033805-28-5 (free acid)

Molecular Weight (MW)
546.93
Formula
C25H22ClF3N6O3
CAS No.
1033805-28-5
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Solubility (In vitro)
DMSO: 10 mM
Water: < 1 mg/mL
Ethanol: < 1 mg/mL
Solubility (In vivo)
O=C(O)[CH](N)CC1=CC=C(C2=NC(N)=NC(O[CH](C3=CC=C(Cl)C=C3N4N=C(C)C=C4)C(F)(F)F)=C2)C=C1
Synonyms
LP778902; LP 778902; LP-778902

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 5mg
Available: In stock
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