Pluripotin (SC1)

Description: Pluripotin (also known as SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Pluripotin inhibits in vitro kinase activity of RSK2 with EC50 of 2.5+/-1.8 uM. It maintains embryonic stem cell (ESC) self-renewal. Simultaneous inhibition of both protein activities is required and sufficient for SC1’s effects on mES cells. SC1 activates Ras by inhibition of RasGAP function. SC1 improved the derivation efficiency and pluripotency of ES cells from C57BL/6. Three types of pluripotent stem cells (fES, ntES, and iPS cells) of the C57BL/6 background could generate full-term pups with high efficiency when cultured with SC1.

References: Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17266-71; PLoS One. 2014 Sep 11; 9(9):e106916.