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Description: NSC19005 (Betahistine EP Impurity C) is an impurity of Betahistine and is structurally related to Betahistine. NSC19005 is a dimer of Betahistine. Betahistine is a potent, orally bioactive and well-tolerated histamine H1receptor agonist and H3 receptor antagonist used for the study ofrheumatoid arthritis (RA).
References:
1. MuriloB. M. de Mello, et al. Characterization and in silico MutagenicAssessment of a New Betahistine Degradation Impurity. J. Braz. Chem.Soc. vol.30 no.7 Sao Paulo July 2019 Epub July 04, 2019
2. PoyurovskyM, et al. The effect of betahistine, a histamine H1 receptor agonist/H3antagonist, on olanzapine-induced weight gain in first-episodeschizophrenia patients. Int Clin Psychopharmacol. 2005 Mar; 20(2):101-3.
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