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Cilengitide (EMD 121974)

Cilengitide (EMD 121974)

Item no.	V2806-5mg
Manufacturer	InvivoChem LLC
CASRN	188968-51-6
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	188968-51-6
Available
Description	InvivoChem Cat #:V2806CAS #:188968-51-6Purity >=98% Description: Cilengitide (also known as EMD 121974, NSC 707544) is a highly potent integrin inhibitor for the alphavbeta3 receptor and the alphavbeta5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; it showed ca.10-fold selectivity against gpIIbIIIa. Cilengitide is a cyclic Arg-Gly-Asp based peptide with potential antineoplastic activity and has been extensively studied for its anticancer application. The mechanism of action for cilengitide is to bind to and inhibit the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. Cilengitide is currently undergoing phase 2 clinical trials, and the European Medicines Agency has granted cilengitide orphan drug status. References: Cancers (Basel). 2017; 9(9): 117; Genes Cancer. 2011; 2(12):1159-65; Cancer Res. 2002; 62(15):4263-72. Related CAS#: 188968-51-6 (free base); 199807-35-7 (TFA salt) 188968-51-6 (free base);
Molecular Weight (MW)	588.66
Formula	C??H??N?O?
CAS No.	188968-51-6 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 40 mg/mL
	Water: >= 30 mg/mL
	Ethanol: N/A
SMILES Code	O=C(NCC(N[CH](C(N[CH](CC1=CC=CC=C1)C(N([CH]2C(C)C)C)=O)=O)CC(O)=O)=O)[CH](CCCNC(N)=N)NC2=O
Synonyms	Cilengitide; EMD 121974; EMD-121974; EMD121974; NSC-707544; NSC 707544; NSC707544; EMD-85189; EMD 85189; EMD85189; D-03497; D03497; D 03497
Chemical Name	2-((2S, 5R, 8S, 11S)-5-benzyl-11-(3-((diaminomethylene)amino)propyl)-8-isopropyl-7-methyl-3, 6, 9, 12, 15-pentaoxo-1, 4, 7, 10, 13-pentaazacyclopentadecan-2-yl)acetic acid

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Amount: 5 mg

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