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azeliragon-free-base

azeliragon-free-base

Item no.	V2883-5mg
Manufacturer	InvivoChem LLC
CASRN	603148-36-3
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	603148-36-3
Available
Description	InvivoChem Cat #:V2883CAS #:603148-36-3 Purity >=98% Description: Azeliragon (also known as TTP488 and PF-04494700) is a potent and orally bioavailable RAGE (Receptor for Advanced Glycation End products) inhibitor that has the potential for the treatment of mild-to-moderate Alzheimer's disease and cerebral amyloid angiopathy. RAGE is a pattern recognition receptor that affects the movement of amyloid (a biomarker for Alzheimer's disease) into the brain. In preclinical studies, azeliragon decreased brain amyloid in mice and improved their performance on behavior tests. Azeliragon has been shown to be involved in adaptive immune responses. It is currently in Phase 3 clinical trial. References: BMC Neurol. 2014 Jan 15; 14:12; Front Aging Neurosci. 2014 Oct 20; 6:290. Related CAS#: 603148-36-3 (free base); 1284150-65-7 (2HCl)
Molecular Weight (MW)	532.12
Formula	C32H38ClN3O2
CAS No.	603148-36-3 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: < 1 mg/mL
	Ethanol: N/A
SMILES Code	CCN(CC)CCCOC1=CC=C(C2=CN(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3)C(CCCC)=N2)C=C1
Synonyms	PF-04494700; PF 04494700; PF04494700; Azeliragon; TTP488; TTP-488; TTP 488;

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