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A 438079

A 438079

Item no.	V28878-5mg
Manufacturer	InvivoChem LLC
CASRN	899507-36-9
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	899507-36-9
Available
Description	InvivoChem Cat #:V28878CAS #:899507-36-9Purity >=98% Description:A-438079 HCl is a novel, potent, and selective P2X7 receptor antagonistwith pIC50 of 6.9. A438079 protects against acetaminophen-induced liverinjury by inhibiting p450 isoenzymes, not by inflammasome activation.A-438079 reduced electrographic and clinical seizure severity duringstatus epilepticus and reduced seizure-induced neuronal death in theneocortex. Blockade of P2X(7) receptors may represent a novel protectivestrategy for striatal DA terminals in Parkinson's disease. References: Neuroscience. 2007 Jun 8; 146(4):1817-28; CNS Neurosci Ther. 2014 Jun; 20(6):556-64. Related CAS#: 899507-36-9 (free base) 899431-18-6 (HCl) Description:A-438079 HCl is a novel, potent, and selective P2X7 receptor antagonistwith pIC50 of 6.9. A438079 protects against acetaminophen-induced liverinjury by inhibiting p450 isoenzymes, not by inflammasome activation.A-438079 reduced electrographic and clinical seizure severity duringstatus epilepticus and reduced seizure-induced neuronal death in theneocortex. Blockade of P2X(7) receptors may represent a novel protectivestrategy for striatal DA terminals in Parkinson's disease. Description: References: Neuroscience. 2007 Jun 8; 146(4):1817-28; CNS Neurosci Ther. 2014 Jun; 20(6):556-64. References: Related CAS#: 899507-36-9 (free base) 899431-18-6 (HCl) 899431-18-6 (HCl)

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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Delivery expected until 9/4/2025

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