JK184

Item no.	V2942-5mg
Manufacturer	InvivoChem LLC
CASRN	315703-52-7
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	315703-52-7
Available
Description	InvivoChem Cat #:V2942CAS #:315703-52-7Purity >=98% Description: JK184 is a novel and potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells. JK184 can specially inhibit glioma (Gli)-dependent transcriptional activity in the Hedgehog (Hh) pathway in a dose dependent manner and showed great promise for cancer therapeutics. JK184 significantly inhibits proliferation of HUVECs with IC50 of 6.3 ug/mL after three days incubation. To evaluate anti-tumor effect of JK184, MTT assay is conducted in Panc-1 and BxPC-3 cells after administration with indicated concentrations of compounds, half maximal inhibitory concentration (IC50) of JK184 (23.7 ng/mL in anc-1 and 34.3 ng/mL in BxPC-3). Description: References: Nanoscale. 2015 Feb 14; 7(6):2609-24; Breast Cancer Res. 2014 Sep 25; 16(5):444. References:
Molecular Weight (MW)	350.44
Formula	C19H18N4OS
CAS No.	315703-52-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM in DMSO
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	CC1=C(C2=CSC(NC3=CC=C(OCC)C=C3)=N2)N4C=CC=CC4=N1
Synonyms	JK-184; JK 184; JK184

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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