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PF-3274167

PF-3274167

Item no.	V2948-5mg
Manufacturer	InvivoChem LLC
CASRN	900510-03-4
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	900510-03-4
Available
Description	InvivoChem Cat #:V2948CAS #:900510-03-4Purity >=98% Description: Cligosiban (formerly known as PF-3274167) is a novel, potent, selective and high-affinity nonpeptide antagonist of oxytocin receptor (OTR) with Ki of 9.5 nM. PF-3274167 displayed promising in vivo pharmacokinetics and significantly improved aqueous solubility over related compounds containing a biaryl substituent. Oxytocin receptor is a G protein-coupled receptor/protein which functions as receptor for the hormone and neurotransmitter oxytocin. Oxytocin receptors are also present in the central nervous system. PF-3274167 is a high-affinity nonpeptide oxytocin receptor (OTR) antagonist, nM. Description: References: Bioorg Med Chem Lett. 2010 Jan 15; 20(2):516-20.J Med Chem. 2015 Mar 12; 58(5):2547-52 References:
Molecular Weight (MW)	419.84
Formula	C19H19ClFN5O3
CAS No.	900510-03-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM in DMSO
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	COC1=NC=C(N2C(N3CC(OC4=CC=C(F)C=C4Cl)C3)=NN=C2COC)C=C1
Synonyms	cligosiban; PF-03274167; PF 03274167; PF03274167; PF-3274167; PF 3274167; PF3274167

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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