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szl-p1-41

szl-p1-41

Item no.	V2952-5mg
Manufacturer	InvivoChem LLC
CASRN	222716-34-9
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	222716-34-9
Available
Description	InvivoChem Cat #:V2952CAS #:222716-34-9Purity >=98% Description: SZL P1-41 is a Skp2 inhibitor that phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival, Akt-mediated glycolysis as well as triggering p53-independent cellular senescence.The reference concentration is 5 uM. SZL P1-41 restricts cancer cell survival through triggering p53-independent cellular senescence and inhibiting aerobic glycolysis. SZL P1-41 exhibits potent anti-tumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival. Description: References: Cell. 2013 Aug 1; 154(3):556-68. References:
Molecular Weight (MW)	420.52
Formula	C24H24N2O3S
CAS No.	222716-34-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM in DMSO
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
SMILES	O=C1C(C2=NC3=CC=CC=C3S2)=COC4=C(CN5CCCCC5)C(O)=C(CC)C=C14
Synonyms	SKP2 E3 Ligase Inhibitor III; SZL-P1-41; SZL P1 41; SZLP141;

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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