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Description: Flavoxate is an anticholinergic (AChR) agent that binds and inhibits muscarinic receptors, thereby suppressing the micturition reflex and increases urinary bladder capacity by modifying the micturition center in the brain stem. As an anticholinergic, Flavoxate has the potential to be used in various urinary syndromes and as an antispasmodic. Flavoxate (3 mg/kg, i.v.) completely abolished rhythmic bladder contractions in vehicle-pretreated rats, but not in PTX-pretreated rats. These findings suggest that signal transduction via Gi-coupled receptors is involved, at least in part, in the inhibition of the micturition reflex by flavoxate in rats.
References: Brain Res. 1996 Jul 15; 727(1-2):91-8.
Related CAS#: 3717-88-2 (HCl salt); 15301-69-6 (free base)
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