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ICA-121431

ICA-121431

Item no.	V2997-5mg
Manufacturer	InvivoChem LLC
CASRN	313254-51-2
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	313254-51-2
Available
Description	InvivoChem Cat #: V2997CAS #:313254-51-2Purity >=98% Description: ICA-121431 is a potent, highly selective small molecule inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels with IC50 of 19 nM. It exhibit up to 1, 000-fold selectivity for human Nav1.3/Nav1.1 (ICA-121431, IC50, 19 nM) vs. other TTX-sensitive or resistant (i.e., Nav1.5) sodium channels, in other words, it has little or no activity against human Nav1.5 or Nav1.7 channels. Voltage-gated sodium channels initiate action potentials in brain neurons, and sodium channel blockers are used in therapy of epilepsy. Description: References: Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):E2724-32. References:
Molecular Weight (MW)	449.54
Formula	C23H19N3O3S2
CAS No.	313254-51-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 40 mg/mL
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	O=C(NC1=CC=C(S(=O)(NC2=NC=CS2)=O)C=C1)C(C3=CC=CC=C3)C4=CC=CC=C4
Synonyms	ICA-121431; ICA 121431; ICA121431.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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