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Description: Procaine (also known as Novocaine HCl), the HCl salt of the local anestheticProcaine, is an inhibitor of sodium channel, NMDA receptor and nAChRwith IC50 of 60 uM, 0.296 mM and 45.5 uM, which is also an inhibitor of5-HT3 with KD of 1.7 uM. Procaine acts mainly by inhibiting sodiuminflux through voltage gated sodium channels in the neuronal cellmembrane of peripheral nerves. Procaine has also been shown to bind orantagonize the function of N-methyl-D-aspartate (NMDA) receptors as wellas nicotinic acetylcholine receptors and the serotonin receptor-ionchannel complex.
References: Anesth Analg. 1998 Oct; 87(4):885-9; Br J Anaesth. 2006 Jan; 96(1):77-87.
Related CAS #:51-06-9 (free base) 51-05-8 (HCl)
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