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Description: Demethyleneberberine is a potent and naturally occuring mitochondria-targeted antioxidant. Demethyleneberberine alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-kappaB pathway and regulating the balance of Th cells. Demethyleneberberine could serve as a AMPK activator for treating non-alcoholic fatty liver disease (NAFLD).
References: Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrialdysfunction, oxidative stress, and steatosis in alcoholic liver diseasemouse model. J Pharmacol Exp Ther. 2015 Jan; 352(1):139-47.
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