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OSS-128167

OSS-128167

Item no.	V3140-5mg
Manufacturer	InvivoChem LLC
CASRN	887686-02-4
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	887686-02-4
Available
Description	InvivoChem Cat #:V3140CAS #:887686-02-4 Purity >=98% Description: OSS_128167 (formerly SIRT6-IN-1) is a novel, potent and selective SIRT6 inhibitor with IC50 of 89, 1578 and 751 uM for SIRT6, SIRT1 and SIRT2, respectively. Although OSS_128167 inhibits SIRT6 in the micromolar range, it shows excellent selectivity, as its IC50 value for SIRT6 is approximately 17 times lower in comparison to the IC50 for SIRT1 and 9 times lower than SIRT2. OSS_128167 at 200 uM induces chemosensitization in primary multiple myeloma (MM) cells (NCI-H929), as well as in melphalan-resistant (LR-5) and doxorubicin-resistant (Dox40) MM cell line. Description: References: J Med Chem. 2014 Jun 12; 57(11):4796-804; Blood. 2016 Mar 3; 127(9):1138-50. References:
Molecular Weight (MW)	366.32
Formula	C19H14N2O6
CAS No.	887686-02-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 73 mg/mL (199.3 mM)
	Water: < 1mg/mL
	Ethanol: < 1mg/mL
Chemical Name	5-(3-(furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid
Synonyms	SIRT6-IN-1; OSS-128167; OSS128167; OSS 128167;
SMILES Code	C1=CC(NC(=O)C2=CC=CO2)=CC(C(=O)NC2=CC=C(O)C(C(O)=O)=C2)=C1

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