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H3B-5942

H3B-5942

Item no.	V31869-5mg
Manufacturer	InvivoChem LLC
CASRN	2052128-15-9
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2052128-15-9
Available
Description	InvivoChem Cat #:V31869CAS #:2052128-15-9Purity >=98% Description: H3B-5942 is a selective, irreversible (covalent) and orally bioavailable estrogen receptor antagonist, inactivating both wild-type and mutant ERalpha by targeting Cys530, with Kis of 1 nM and 0.41 nM, respectively. H3B-5942 reduces ERalpha target gene GREB1, shows potent antitumor activity both in multiple cell lines or animals bearing ERalphaWT or ERalpha mutations. References: Puyang X, et al. Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERalphaWT and ERalphaMUT Breast Cancer. Cancer Discov. 2018 Sep; 8(9):1176-1193. Related CAS #: 2052132-46-2 (HCl) 2052128-15-9 (free base)

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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