MMAF Hydrochloride

Description: Monomethyl auristatin F (MMAF) HCl is a highly potent tubulin inhibitor and an antineoplastic agent used as a warhead in ADCs (antibody-drug conjugates) such as vorsetuzumab mafodotin and SGN-CD19A. In International Nonproprietary Names for MMAF-antibody-conjugates, the name mafodotin refers to MMAF plus its attachment structure to the antibody. MMAF is actually desmethyl-auristatin F; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin F itself.

References: Kostova V, Dransart E, Azoulay M, Brulle L, Bai SK, Florent JC, Johannes L, Schmidt F. Targeted Shiga toxin-drug conjugates prepared via Cu-free click chemistry. Bioorg Med Chem. 2015 Nov 15; 23(22):7150-7.

Related CAS: 1799706-65-2 (sodium); 1415246-68-2 (HCl); 745017-94-1 (free base)