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jnj-16259685

jnj-16259685

Item no.	V3326-5mg
Manufacturer	InvivoChem LLC
CASRN	409345-29-5
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	409345-29-5
Available
Description	InvivoChem Cat #:V3326CAS #:409345-29-5 Purity >=98% Description: JNJ16259685 is a novel, potent, selective and non-competitive antagonist of mGlu1 receptor with IC50 of 19 nM. It inhibits the synaptic activation of mGlu1 in a concentration-dependent manner. JNJ16259685 produced very minimal effects on locomotor activity and posture up to a dose of 30 mg/kg. Motor skill was unaffected for well-learned tasks (up to 30 mg/kg) in rats, but impaired in mice. Both rats and mice rats were profoundly impaired (0.3 mg/kg) in the acquisition of a novel motor skill (rotarod). Description: References: Eur J Pharmacol. 2008 May 31; 586(1-3):217-20; Pharmacol Biochem Behav. 2011 Apr; 98(2):181-7; Neuropharmacology. 2004 Dec; 47(7):961-72.. References:
Molecular Weight (MW)	325.41
Formula	C20H23NO3
CAS No.	409345-29-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Chemical Name	(3, 4-dihydro-2H-pyrano[2, 3-b]quinolin-7-yl)(4-methoxycyclohexyl)methanone
Synonyms	JNJ16259685; JNJ 16259685; JNJ-16259685
SMILES Code	O=C(C1=CC=C2N=C3C(CCCO3)=CC2=C1)C4CCC(OC)CC4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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