YS 49

Item no.	V3410-5mg
Manufacturer	InvivoChem LLC
CASRN	132836-42-1
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	132836-42-1
Available
Description	InvivoChem Cat #:V3410CAS #:132836-42-1Purity >=98% Description: YS-49 is a novel and potent anti-inflammatory agent and activator of PI3K/Akt signaling that inhibits Ang II-stimulated proliferation of VSMCs via induction of HO-1. YS-49 regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1. YS 49 induced HO-1 protein production in a dose-and time-dependent manner in VSMCs. Treatment with YS 49 significantly and dose-dependently inhibited Ang II-induced VSMC proliferation, ROS production, and phosphorylation of JNK, but not P38 MAP kinase or ERK1/2. YS 49 has potential as a therapeutic strategy for the pathogenesis of Ang II-related vascular diseases such as hypertension and atherosclerosis, via the induction of HO-1 gene activity. References: Life Sci. 2008; 82(11-12):600-7.
	Name: YS-49 HBr CAS#: 132836-42-1 Chemical Formula: C??H??BrNO? Molecular Weight: 386.28
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: YS-49; YS49; YS 49; YS-49 HBr; YS-49 hydrobromide Chemical Name: 1, 2, 3, 4-Tetrahydro-1-(1-naphthalenylmethyl)-6, 7-Isoquinolinediol hydrobromide InChi Key: QHCUNMLYODPTIU-UHFFFAOYSA-N InChi Code: InChI=1S/C20H19NO2.BrH.H2O/c22-19-11-15-8-9-21-18(17(15)12-20(19)23)10-14-6-3-5-13-4-1-2-7-16(13)14; ; /h1-7, 11-12, 18, 21-23H, 8-10H2; 1H; 1H2 SMILES Code: OC1=CC2=C(C(CC3=C4C=CC=CC4=CC=C3)NCC2)C=C1O.[H]Br

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 5 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 6 days

Compare

Add to wishlist

Get an offer