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oclacitinib

oclacitinib

Item no.	V3419-5mg
Manufacturer	InvivoChem LLC
CASRN	1208319-26-9
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1208319-26-9
Available
Description	InvivoChem Cat #:V3419CAS #:1208319-26-9Purity >=98% Description: Oclacitinib (formerly also known as PF-03394197) is a novel and potent inhibitor of JAK (Janus kinase) family members with IC50 values ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM. Oclacitinib did not inhibit a panel of 38 non-JAK kinases and is the most potent at inhibiting JAK1. Oclacitinib also inhibits the function of JAK1-dependent cytokines involved in allergy and inflammation as well as pruritus. Cclacitinib is a targeted therapy that selectively inhibits JAK1-dependent cytokines involved in allergy, inflammation, and pruritus and suggests these are the mechanisms by which oclacitinib effectively controls clinical signs associated with allergic skin disease in dogs. Description: References: Vet Dermatol. 2013 Oct; 24(5):479-e114; J Vet Pharmacol Ther. 2014 Aug; 37(4): 317–324. References: Related CAS: 1208319-26-9 (free base); 1640292-55-2 (maleate)
Molecular Weight (MW)	337.44
Formula	C15H23N5O2S
CAS No.	1208319-26-9 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 90 mg/mL (198.5 mM) for maleate salt
	Water: 18 mg/mL (39.7 mM) for maleate salt
	Ethanol: 90 mg/mL (198.5 mM) for maleate salt
SMILES Code	O=S(C[CH]1CC[CH](N(C)C2=C3C(NC=C3)=NC=N2)CC1)(NC)=O
Synonyms	PF-03394197; PF03394197; PF 03394197; Apoquel.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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