« Back
Home /
ICI-118551 HCl

ICI-118551 HCl

Item no.	V3431-5mg
Manufacturer	InvivoChem LLC
CASRN	72795-01-8
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	72795-01-8
Available
Description	InvivoChem Cat #:V3431CAS #:72795-01-8Purity >=98% Description: ICI-118551 HCl, the hydrochloride salt of ICI-118551, is a novel, potent and highly selective beta2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for beta2, beta1 and beta3 receptors, respectively. beta(2)-adrenoceptors are important modulators of vascular tone, particularly in the pulmonary circulation. ICI 118551 binding directs the beta(2)AR to a G(i)-coupled form and away from the G(s)-coupled form (ligand-directed trafficking). ICI 118, 551 effectively acts as an agonist at the G(i)-coupled beta(2)AR, producing a direct negative inotropic effect. Conditions where beta(2)ARs are present and G(i) is raised (failing human heart, TGbeta(2) mouse heart) predispose to the appearance of the negative inotropic effect. References: Circulation. 2002 May 28; 105(21):2497-503; Hypertension. 2009 Jul; 54(1):157-63. Related CAS #: 72795-01-8 (HCl) 72795-26-7 (free base) 91021-57-7 (racemic)
	Name: ICI-118551 HCl CAS#: 72795-01-8 (HCl) Chemical Formula: C17H28ClNO2 Exact Mass: Molecular Weight: 313.87 Elemental Analysis: C, 65.06; H, 8.99; Cl, 11.29; N, 4.46; O, 10.19
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: ICI118551; ICI 118551; ICI-118551; ICI118, 551; ICI 118, 551; ICI-118, 551; ICI-118551 HCl. Chemical Name: (2R, 3R)-3-(isopropylamino)-1-((7-methyl-2, 3-dihydro-1H-inden-4-yl)oxy)butan-2-ol hydrochloride InChi Key: KBXMBGWSOLBOQM-CACIRBSMSA-N InChi Code: InChI=1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17; /h8-9, 11, 13, 16, 18-19H, 5-7, 10H2, 1-4H3; 1H/t13-, 16+; /m1./s1 SMILES Code: C[CH](NC(C)C)[CH](O)COC1=CC=C(C)C2=C1CCC2.[H]Cl

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 5 mg

available

Delivery expected until 10/2/2025

Express Delivery: Save 22 days

Compare

Add to wishlist

Get an offer