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ICI-118551 HCl

ICI-118551 HCl

Item no.	V3431-5mg
Manufacturer	InvivoChem LLC
CASRN	72795-01-8
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	72795-01-8
Available
Description	InvivoChem Cat #:V3431CAS #:72795-01-8Purity >=98% Description: ICI-118551 HCl, the hydrochloride salt of ICI-118551, is a novel, potent and highly selective beta2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for beta2, beta1 and beta3 receptors, respectively. beta(2)-adrenoceptors are important modulators of vascular tone, particularly in the pulmonary circulation. ICI 118551 binding directs the beta(2)AR to a G(i)-coupled form and away from the G(s)-coupled form (ligand-directed trafficking). ICI 118, 551 effectively acts as an agonist at the G(i)-coupled beta(2)AR, producing a direct negative inotropic effect. Conditions where beta(2)ARs are present and G(i) is raised (failing human heart, TGbeta(2) mouse heart) predispose to the appearance of the negative inotropic effect. References: Circulation. 2002 May 28; 105(21):2497-503; Hypertension. 2009 Jul; 54(1):157-63. Related CAS #: 72795-01-8 (HCl) 72795-26-7 (free base) 91021-57-7 (racemic)
	Name: ICI-118551 HCl CAS#: 72795-01-8 (HCl) Chemical Formula: C17H28ClNO2 Exact Mass: Molecular Weight: 313.87 Elemental Analysis: C, 65.06; H, 8.99; Cl, 11.29; N, 4.46; O, 10.19
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: ICI118551; ICI 118551; ICI-118551; ICI118, 551; ICI 118, 551; ICI-118, 551; ICI-118551 HCl. Chemical Name: (2R, 3R)-3-(isopropylamino)-1-((7-methyl-2, 3-dihydro-1H-inden-4-yl)oxy)butan-2-ol hydrochloride InChi Key: KBXMBGWSOLBOQM-CACIRBSMSA-N InChi Code: InChI=1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17; /h8-9, 11, 13, 16, 18-19H, 5-7, 10H2, 1-4H3; 1H/t13-, 16+; /m1./s1 SMILES Code: C[CH](NC(C)C)[CH](O)COC1=CC=C(C)C2=C1CCC2.[H]Cl

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Amount: 5 mg

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Delivery expected until 9/4/2025

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