BSJ-03-123

InvivoChem Cat #:V3439CAS #:2361493-16-3Purity >=98%

Description: BSJ-03-123 is a novel, potent cyclin-dependent kinase 6 (CDK6)-selective small-molecule degrader (PROTAC: proteolysis targeting chimera). It is a phthalimide-based degrader that exploits protein-interface determinants to achieve proteome-wide selectivity for the degradation of cyclin-dependent kinase 6 (CDK6). Pharmacologic CDK6 degradation targets a selective dependency of acute myeloid leukemia cells, and transcriptomics and phosphoproteomics profiling of acute degradation of CDK6 enabled dynamic mapping of its immediate role in coordinating signaling and transcription.

References: Cell Chem Biol. 2019 Feb 21; 26(2):300-306.e9.

-20C for 3 years in powder form

Synonym: BSJ-03123; BSJ03123; BSJ 03123; BSJ-03-123; BSJ03-123; BSJ 03-123
Chemical Name: N-(2-(2-(2-(2-(4-(6-((3-acetyl-1-cyclopentyl-4-methyl-2-oxo-1, 2-dihydro-1, 6-naphthyridin-7-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-2-((2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxoisoindolin-4-yl)oxy)acetamide
InChi Key: PHXAASMYZCBYHV-UHFFFAOYSA-N
InChi Code: InChI=1S/C48H57N9O11/c1-30-35-28-51-40(26-37(35)56(32-6-3-4-7-32)47(63)43(30)31(2)58)52-39-12-10-33(27-50-39)55-17-15-54(16-18-55)19-21-66-23-25-67-24-22-65-20-14-49-42(60)29-68-38-9-5-8-34-44(38)48(64)57(46(34)62)36-11-13-41(59)53-45(36)61/h5, 8-10, 12, 26-28, 32, 36H, 3-4, 6-7, 11, 13-25, 29H2, 1-2H3, (H, 49, 60)(H, 50, 51, 52)(H, 53, 59, 61)
SMILES Code: O=C(NCCOCCOCCOCCN1CCN(C2=CC=C(NC3=CC4=C(C=N3)C(C)=C(C(C)=O)C(N4C5CCCC5)=O)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O