JavaScript seems to be disabled in your browser. You must have JavaScript enabled in your browser to utilize the functionality of this website.
Description: BMS 299897 is a novel and potent sulfonamide gamma-secretase inhibitor with an IC50 of 7 nM for Abeta production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP). BMS-299897 blocked the increase in Abeta(1-42) content and decreased Abeta(1-40) levels significantly. The compound did not affect Abeta(25-35)-induced increase in hippocampal lipid peroxidation. Behaviorally, BMS-299897 blocked the Abeta(25-35)-induced deficits in spontaneous alternation or novel object recognition, using a 1h intertrial time interval. BMS-299896 failed to affect the passive avoidance impairments or novel object recognition, using a 24h intertrial time interval. These results confirmed that Abeta(25-35) injection provoked an accumulation in endogenous Abeta(1-42), an effect blocked by gamma-secretase inhibition. This Abeta(1-42) accumulation marginally contributed to the toxicity or long-term memory deficits. However, since the seeded Abeta(1-42) affected short-term memory, the rapid Abeta(25-35) injection Alzheimer's disease model could be used to screen the activity of new secretase inhibitors.
References: PLoS One. 2015 Feb 24; 10(2):e0118379; Eur J Pharmacol. 2013 Jan 5; 698(1-3):193-9.
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
Request Data Sheet
Request product datasheet
Request safety datasheet
Compare
Add to wishlist
Get an offer
Request delivery time
Ask a technical question
Submit a bulk request
sales@hoelzel.de
« Back
Subscribe, get 15% off every fifth order and have your items delivered on time!
Forgot Your Password?
Not yet registered? Create account here!