Comparison

bms-299897

Item no. V3492-5mg
Manufacturer InvivoChem LLC
CASRN 290315-45-6
Amount 5mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias 290315-45-6
Available
Description
InvivoChem Cat #:V3492CAS #:290315-45-6Purity >=98%

Description: BMS 299897 is a novel and potent sulfonamide gamma-secretase inhibitor with an IC50 of 7 nM for Abeta production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP). BMS-299897 blocked the increase in Abeta(1-42) content and decreased Abeta(1-40) levels significantly. The compound did not affect Abeta(25-35)-induced increase in hippocampal lipid peroxidation. Behaviorally, BMS-299897 blocked the Abeta(25-35)-induced deficits in spontaneous alternation or novel object recognition, using a 1h intertrial time interval. BMS-299896 failed to affect the passive avoidance impairments or novel object recognition, using a 24h intertrial time interval. These results confirmed that Abeta(25-35) injection provoked an accumulation in endogenous Abeta(1-42), an effect blocked by gamma-secretase inhibition. This Abeta(1-42) accumulation marginally contributed to the toxicity or long-term memory deficits. However, since the seeded Abeta(1-42) affected short-term memory, the rapid Abeta(25-35) injection Alzheimer's disease model could be used to screen the activity of new secretase inhibitors.

References: 2015 Feb 24; 10(2):e0118379; 2013 Jan 5; 698(1-3):193-9.

BMS 299897
Name: BMS-299897
CAS#: 290315-45-6
Chemical Formula: C24H21ClF3NO4S
Exact Mass: 511.08319
Molecular Weight: 511.94
Elemental Analysis: C, 56.31; H, 4.13; Cl, 6.93; F, 11.13; N, 2.74; O, 12.50; S, 6.26
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Technical Information
Synonym: BMS299897; BMS 299897; BMS-299897
Chemical Name: (R)-4-(2-(1-(4-chloro-N-(2, 5-difluorophenyl)phenylsulfonamido)ethyl)-5-fluorophenyl)butanoic acid
InChi Key: IZAOBRWCUGOKNH-OAHLLOKOSA-N
InChi Code: InChI=1S/C24H21ClF3NO4S/c1-15(21-11-7-18(26)13-16(21)3-2-4-24(30)31)29(23-14-19(27)8-12-22(23)28)34(32, 33)20-9-5-17(25)6-10-20/h5-15H, 2-4H2, 1H3, (H, 30, 31)/t15-/m1/s1
SMILES Code: O=C(O)CCCC1=CC(F)=CC=C1[CH](N(C2=CC(F)=CC=C2F)S(=O)(C3=CC=C(Cl)C=C3)=O)C

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 5mg
Available: In stock
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