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Description: GSK 650394 is a novel and potent competitive inhibitor of SGK (serum and glucocorticoid-regulated kinase 1) with IC50 of 62 nM and 103 nM for SGK1 and SGK2 in the SPA assay respectively. GSK650394 quantitatively blocks the effect of androgens on LNCaP cell growth.
References: Cancer Res. 2008 Sep 15; 68(18):7475-83.
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