GSK805

Item no.	V3596-50mg
Manufacturer	InvivoChem LLC
CASRN	1426802-50-7
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3596CAS #:1426802-50-7Purity >=98% Description: GSK805 is a novel, potent, and orally bioavailable RORgammagamma Inhibitor with pIC50 of 8.4 and > 8.2 for RORgamma FRET assay and Th17 assay. Structure-activity relationship exploration on the biaryl moiety led to discovery of potent RORgammat inhibitors with good oral bioavailability and CNS penetration. GSK805 demonstrated excellent in vivo efficacy in EAE mice dose dependently with once daily oral administration. References: ACS Med Chem Lett. 2015 May 26; 6(7):787-792.
	Name: GSK805 CAS#: 1426802-50-7 Chemical Formula: C23H18Cl2F3NO4S Exact Mass: 531.0286 Molecular Weight: 532.3552 Elemental Analysis: C, 51.89; H, 3.41; Cl, 13.32; F, 10.71; N, 2.63; O, 12.02; S, 6.02
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: RORgammat Inverse Agonist II; GSK805; GSK805; GSK805; ROR gamma-t-IN-1; IUPAC/Chemical Name: N-[2, 6-dichloro-2'-(trifluoromethoxy)[1, 1'-biphenyl]-4-yl]-4-(ethylsulfonyl)-benzeneacetamide InChi Key: CEICQMBWAQAIQX-UHFFFAOYSA-N InChi Code: InChI=1S/C23H18Cl2F3NO4S/c1-2-34(31, 32)16-9-7-14(8-10-16)11-21(30)29-15-12-18(24)22(19(25)13-15)17-5-3-4-6-20(17)33-23(26, 27)28/h3-10, 12-13H, 2, 11H2, 1H3, (H, 29, 30) SMILES Code: O=C(NC1=CC(Cl)=C(C2=CC=CC=C2OC(F)(F)F)C(Cl)=C1)CC3=CC=C(S(=O)(CC)=O)C=C3

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Amount: 50 mg

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Delivery expected until 9/4/2025

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