Comparison

Alvimopan monohydrate

Item no. V3723-5mg
Manufacturer InvivoChem LLC
CASRN 1383577-62-5
Amount 5 mg
Quantity options 100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias 1383577-62-5
Available
Description
InvivoChem Cat #:V3723CAS #:1383577-62-5 Purity >=98%

Description: Alvimopan (also known as ADL 8-2698; LY 246736; HSDB-7704) is a novel peripheral micro opioid antagonist in clinical development for the management of post-operative ileus and opioid-induced bowel dysfunction. The long duration of action of alvimopan might be related to a slower dissociation rate from the micro opioid receptor compared to other shorter acting antagonists. The dissociation rate of alvimopan from the micro opioid receptor (t(1/2)=30--44 min) was comparable to that of the long acting partial agonist buprenorphine (t(1/2)=44 min), but was slower than those of the antagonists naloxone (t(1/2)=0.82 min) and N-methylnaltrexone (t(1/2)=0.46 min). Also, increases in the apparent affinities and potencies of buprenorphine and alvimopan, but not of naloxone and methylnaltrexone, were observed upon preincubation with the micro opioid receptor. Consistent with its long duration of action, alvimopan has a slow dissociation rate from the micro opioid receptor compared to other shorter acting antagonists and may be more potent if administered prior to dosing with exogenous opioids.

References: 2006 Jan; 20(1):64-70; 2005 Sep 27; 520(1-3):29-36.

Related CAS#: 156053-89-3 (free); 170098-38-1 (di-hydrate)

Molecular Weight (MW)
442.56
Formula
C25H34N2O5
CAS No.
1383577-62-5 (mono-hydrate);
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Solubility (In vitro)
DMSO: 92 mg/mL (199.8 mM)
Water: > 1mg/mL
Ethanol: > 1mg/mL
Chemical Name
((S)-2-benzyl-3-((3R, 4R)-4-(3-hydroxyphenyl)-3, 4-dimethylpiperidin-1-yl)propanoyl)glycine monohydrate
Synonyms
LY246736 monohydrate; LY246736; LY-246736; HSDB 7704; HSDB7704 monohydrate; HSDB-7704; ADL 8-2698; ADL8-2698; ADL-8-2698 monohydrate; Alvimopan monohydrate. Brand name: Entereg.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 5 mg
Available: In stock
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