ck-869

Item no.	V3745-25mg
Manufacturer	InvivoChem LLC
CASRN	388592-44-7
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3745CAS #:388592-44-7Purity >=98% Description: CK-869 is a small molecule inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex which is a seven-subunit assembly that nucleates branched actin filaments. The mode of action of CK-869 is to bind to Arp2/3 complex and inhibit nucleation. CK-869 binds to a serendipitous pocket on Arp3 and allosterically destabilizes the short pitch Arp3-Arp2 interface. These results provide key insights into the relationship between conformation and activity in Arp2/3 complex and will be critical for interpreting the influence of the inhibitors on actin filament networks in vivo. References: Chem Biol. 2013 May 23; 20(5):701-12; Biochem Biophys Res Commun. 2018 Feb 12; 496(3):834-839.
Molecular Weight (MW)	394.28
Formula	C17H16BrNO3S
CAS No.	388592-44-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: < 1mg/mL
	Ethanol: < 1mg/mL
Chemical Name	2-(3-Bromophenyl)-3-(2, 4-dimethoxyphenyl)-4-thiazolidinone
Synonyms	CK-869; CK 869; CK869; CK-0157869; CK 0157869; CK0157869

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