« Back
Home /
pf-06454589

pf-06454589

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	10mg
Item no.	V3762-10mg
CASRN	1527473-30-8
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V3762CAS #:1527473-30-8Purity >=98% Description: PF-06454589 is an analog of PF-06447475 which is a highly potent, brain penetrant and selective LRRK2 inhibitor which has been profiled in in vivo safety and pharmacodynamic studies. Leucine rich repeat kinase 2 (LRRK2) has been genetically linked to Parkinson's disease (PD) by genome-wide association studies (GWAS). The most common LRRK2 mutation, G2019S, which is relatively rare in the total population, gives rise to increased kinase activity. As such, LRRK2 kinase inhibitors are potentially useful in the treatment of PD. References: J Med Chem. 2015 Jan 8; 58(1):419-32. Related CAS#:1527473-33-1 (PF-06447475)
Molecular Weight (MW)	284.32
Formula	C14H16N6O
CAS No.	1527473-30-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Chemical Name	4-[5-(1-methylpyrazol-4-yl)-7H-pyrrolo[2, 3-d]pyrimidin-4-yl]morpholine
Synonyms	PF-06454589; PF 06454589; PF06454589

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 10mg

available

Delivery expected until 6/6/2024