tirofiban-hydrochloride

Description: Tirofiban hydrochloride (also known as L700462 or MK383) is a novel non-peptide antagonist of glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) that is used as an antiplatelet drug. Tirofiban is a small molecule inhibitor of the protein-protein interaction between fibrinogen and the platelet integrin receptor GP IIb/IIIa and is the first drug candidate whose origins can be traced to a pharmacophore-based virtual screening lead. Tirofiban Hydrochloride is the hydrochloride salt form of tirofiban, a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation. It is more soluable than Tirofiban. Tirofiban inhibits platelet aggregation of gel-filtered platelets induced by 10 uM ADP with IC50 of 9 nM, but the IC50 for inhibition of human umbilical vein adhesion to vitronectin, which depends on ?vbeta3 vitronectin receptors, is 62 umol/L.

References: J Clin Invest. 1997 Dec 1; 100(11 Suppl):S57-60.

Related CAS#: 144494-65-5 (free base); 150915-40-5 (HCl hydrate); 142373-60-2 (HCl)