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talazoparib-tosylate

talazoparib-tosylate

Item no.	V3865-250mg
Manufacturer	InvivoChem LLC
CASRN	1373431-65-2
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3865CAS #:1373431-65-2 Purity >=98% Description: Talazoparib tosylate (formerly called BMN673 and MDV3800; trade name: Talzenna), the tosylate salt of talazoparib, is an inhibitor of PARP1/2 poly(ADP-ribose) polymerase with potential antineoplastic activity. It inhibits PARP with an IC50 of 0.58 nM in a cell-free assay. It exhibits favorable metabolic stability, oral bioavailability, and pharmacokinetic properties. On Oct 16 2018, Talazoparib was approved by FDA for the treatment of locally advanced or metastatic breast cancer patients with a germline BRCA mutation. References: Clin Cancer Res. 2013 Sep 15; 19(18):5003-15; Clin Cancer Res. 2014 Apr 15; 20(8):2237. Related CAS#:1207456-01-6 (free base); 1207456-00-5; 1207454-56-5 (racemic mixture)
Molecular Weight (MW)	552.56
Formula	C26H22F2N6O4S
CAS No.	1373431-65-2 (tosylate);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 100 mg/mL
	Water: N/A
	Ethanol: N/A
Solubility (In vivo)	O=C1NN=C2C3=C1C=C(F)C=C3N[CH](C4=CC=C(F)C=C4)[CH]2C5=NC=NN5C.OS(=O)(C6=CC=C(C)C=C6)=O
Synonyms	BMN 673 tosylate; BMN673; BMN-673; LT673 tosylate; LT 673; LT-673 tosylate; MDV-3800 tosylate; MDV 3800; MDV3800 tosylate; trade name: Talzenna

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Amount: 250mg

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