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tafenoquine

tafenoquine

Item no.	V3882-5mg
Manufacturer	InvivoChem LLC
CASRN	106635-80-7
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	106635-80-7
Available
Description	InvivoChem Cat #:V3882CAS #:106635-80-7Purity >=98% Description: Tafenoquine (formerly known as WR-238605; Brand name of Krintafel) is an 8-aminoquinoline analog and oral drug developed by GlaxoSmithKline that has been investigated as a potential treatment for malaria, as well as for malaria prevention. Tafenoquine targets leishmania respiratory complex III and induces apoptosis. Tafenoquine has a long half-life of approximately 14 days and is generally safe and well tolerated. In July 2018, United States Food and Drug Administration (US FDA) approved single dose tafenoquine for the radical cure (prevention of relapse) of Plasmodium vivax malaria. References: J Travel Med. 2018 Jan 1; 25(1). doi: 10.1093/jtm/tay110; J Travel Med. 2018 Dec 11. doi: 10.1093/jtm/tay133. Related CAS#:106635-81-8( succinate)
Molecular Weight (MW)	463.50
Formula	C24H28F3N3O3
CAS No.	106635-80-7 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Chemical Name	N4-(2, 6-dimethoxy-4-methyl-5-(3-(trifluoromethyl)phenoxy)quinolin-8-yl)pentane-1, 4-diamine
Synonyms	WR-238605, WR 238605, WR238605
SMILES Code	CC1=CC(=NC2=C1C(=C(C=C2NC(C)CCCN)OC)OC3=CC=CC(=C3)C(F)(F)F)OC

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