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ipi-549

ipi-549

Item no.	V3942-100mg
Manufacturer	InvivoChem LLC
CASRN	1693758-51-8
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3942CAS #:1693758-51-8 Purity >=98% Description: IPI549 is a novel potent and selective small molecule PI3Kgamma (phosphoinositide-3-kinase) inhibitor with IC50 of 16 nM and with > 100-fold selectivity over other lipid and protein kinases. IPI-549 demonstrates favorable pharmacokinetic properties and robust inhibition of PI3K-gamma mediated neutrophil migration in vivo and is currently in Phase 1 clinical evaluation in subjects with advanced solid tumors. References: Nature. 2016 Nov 17; 539(7629):443-447; ACS Med Chem Lett. 2016 Jul 22; 7(9):862-7.
Molecular Weight (MW)	528.58
Formula	C30H24N8O2
CAS No.	1693758-51-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 15 mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	(S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1, 2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1, 5-a]pyrimidine-3-carboxamide
Synonyms	IPI-549; IPI 549; IPI549
SMILES Code	O=C1N(C2=CC=CC=C2)C([CH](NC(C3=C(N=CC=C4)N4N=C3N)=O)C)=CC5=CC=CC(C#CC6=CN(C) N=C6)=C51

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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