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Description: BW-A 78U is a novel and potent PDE4 (phosphodiesterase 4) inhibitor with an IC50 of 3 uM. Adenine derivatives substituted in position 9 have been demonstrated to have potent (PDE) inhibition properties with high selectivity toward PDE4. BW-A 78U fails to significantly inhibit arachidonate release. BW-A 78U is ineffective to inhibit the lipopolysaccharide (LPS)-induced TNF-alpha release.
References: J Pharmacol Exp Ther. 2000 Feb; 292(2):647-53.
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