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pf-04965842

pf-04965842

Item no.	V4059-50mg
Manufacturer	InvivoChem LLC
CASRN	1622902-68-4
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4059CAS #:1622902-68-4 Purity >=98% Description: Abrocitinib (formerly also known as PF-04965842) is a novel, potent and orally bioavailable JAK1 (Janus Kinase 1) inhibitor with IC50s of 29 nM, 803 nM, > 10 000 nM and 1250 nM for JAK1, JAK2, JAK3 and tyrosine kinase (TYK) 2, respectively. It is being investigated for treatment of plaque psoriasis. Physicochemical properties and pharmacokinetic parameters of PF-04965842 are examined in rats following doses of 1 mg/kg iv or 3 mg/kg po. Clearance of PF-04965842 is low relative to total liver blood flow (CL = 26.6 mL/min/kg). Vdss = 1.04 L/kg. T1/2 = 1.1 h. The oral availability of PF-04965842 is 95.6%. PF-04965842 demonstrates efficacy in a dose-responsive manner in a therapeutic rat adjuvant-induced arthritis model. Description: References: J Med Chem. 2018, 61(3):1130-1152. References: Related CAS#:2204280-33-9 (trans-isomer)
Molecular Weight (MW)	323.41
Formula	C14H21N5O2S
CAS No.	1622902-68-4 (cis-isomer)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 65mg/mL
	Water: < 1mg/mL
	Ethanol: < 1mg/mL
Chemical Name	N-((1s, 3s)-3-(methyl(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide
Synonyms	PF-04965842; PF 04965842; PF04965842; Abrocitinib
SMILES Code	CCCS(=O)(N[CH]1C[CH](N(C)C2=C3C(NC=C3)=NC=N2)C1)=O

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Amount: 50mg

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