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azd3229-tosylate

azd3229-tosylate

Item no.	V4154-50mg
Manufacturer	InvivoChem LLC
CASRN	2248003-71-4
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4154CAS #:2248003-71-4 Purity >=98% Description: AZD3229 Tosylate is a novel, potent, pan-KIT mutant inhibitor with low nanomolar growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI50=1-50 nM), with good margin to KDR-driven effects and potential for the Treatment of Gastrointestinal Stromal Tumors. It also inhibits PDGFR mutants (Tel-PDGFRalpha, Tel-PDGFRbeta, V561D/D842V). It also demonstrates excellent cross-species pharmacokinetics, shows strong pharmacodynamic inhibition of target, and is active in several in vivo models of GIST. Selectivity over KDR can be rationalized predominantly by the interaction of water molecules with the protein and ligand in the active site, and its kinome selectivity is similar to the best of the approved GIST agents. Description References: J Med Chem. 2018 Oct 11; 61(19):8797-8810 References: Related CAS#:2248003-60-1 (free base)
	Molecular Weight? 651.71 Formula? C??H??FN?O?S CAS No.? 2248003-71-4 (tosylate)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: AZD3229 tosylate; AZD 3229; AZD-3229 IUPAC/Chemical Name: N-{4-[(6, 7-dimethoxyquinazolin-4-yl)oxy]phenyl}-2-[4-(propan-2-yl)-1H-1, 2, 3-triazol-1-yl]acetamide SMILES Code: COCCOC1=CC(F)=C2C(N=CN=C2NC3=CC=C(NC(CN4C=C(C(C)C)N=N4)=O)C=C3)=C1.CC5=CC=C(S(O)(=O)=O)C=C5

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Amount: 50mg

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