az876

Item no.	V4156-1g
Manufacturer	InvivoChem LLC
CASRN	898800-26-5
Amount	1g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4156CAS #:898800-26-5Purity >=98% Description: AZ-876 is a novel, potent high-affinity agonist of Liver X Receptor (LXR) with Ki values of 0.007 uM and 0.011 uM for human LXRalpha and LXRbeta respectively. AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects. LXR activation with AZ876 attenuated this increase, and significantly reduced TAC-induced increases in heart weight, myocardial fibrosis, and cardiac dysfunction without affecting blood pressure. Liver X receptors (LXRs) transcriptionally regulate inflammation, metabolism, and immunity. Description: References: Eur J Heart Fail. 2015 Mar; 17(3):273-82.; Br J Pharmacol. 2011 Apr; 162(7):1553-63. References:
	Name: AZ-876 CAS#: 898800-26-5 Chemical Formula: C24H29N3O3S Exact Mass: 439.193 Molecular Weight: 439.574 Elemental Analysis: C, 65.58; H, 6.65; N, 9.56; O, 10.92; S, 7.29
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: AZ876; AZ 876; AZ-876, AZ12260493; AZ 12260493; AZ-12260493. IUPAC/Chemical Name: 2-(1, 1-Dimethylethyl)-5-phenyl-4-[[4-(1-piperidinyl)phenyl]amino]-3(2H)-isothiazolone 1, 1-dioxide InChi Key: IVANYIPLGFVBGR-UHFFFAOYSA-N InChi Code: InChI=1S/C24H29N3O3S/c1-24(2, 3)27-23(28)21(22(31(27, 29)30)18-10-6-4-7-11-18)25-19-12-14-20(15-13-19)26-16-8-5-9-17-26/h4, 6-7, 10-15, 25H, 5, 8-9, 16-17H2, 1-3H3 SMILES Code: O=C(C(NC1=CC=C(N2CCCCC2)C=C1)=C3C4=CC=CC=C4)N(C(C)(C)C)S3(=O)=O1

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