BAY885

Item no.	V4176-5mg
Manufacturer	InvivoChem LLC
CASRN	2307249-33-6
Amount	5 mg
Quantity options	100 mg 10 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2307249-33-6
Available
Description	InvivoChem Cat #:V4176CAS #:2307249-33-6Purity >=98% Description: BAY-885 is a novel, highly potent and selective ERK5/MAPK7 inhibitor with IC50 of 40 nM. The availability of a chemical probe to study the role of a specific domain of a protein in a concentration- and time-dependent manner is of high value. BAY-885 was identified by high-throughput screening and subsequent structure-based optimization. ERK5 is a key integrator of cellular signal transduction, and it has been shown to play a role in various cellular processes such as proliferation, differentiation, apoptosis, and cell survival. The inhibition of ERK5 kinase and transcriptional activity with a small molecule did not translate into antiproliferative activity in different relevant cell models, which is in contrast to the results obtained by RNAi technology. Description: References: J Med Chem. 2019 Jan 24; 62(2):928-940. References:
	Name: BAY-885 CAS#: N/A Chemical Formula: C25H28F3N7O2 Exact Mass: 515.2257 Molecular Weight: 515.5412 Elemental Analysis: C, 58.24; H, 5.47; F, 11.06; N, 19.02; O, 6.21
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: BAY-885; BAY 885; BAY885 IUPAC/Chemical Name: (2-amino-4-(trifluoromethoxy)phenyl)(4-(7-(4-methylpiperazin-1-yl)pyrido[3, 2-d]pyrimidin-4-yl)piperidin-1-yl)methanone InChi Key: QXURFIGBRGWPQD-UHFFFAOYSA-N InChi Code: InChI=1S/C25H28F3N7O2/c1-33-8-10-34(11-9-33)17-12-21-23(30-14-17)22(32-15-31-21)16-4-6-35(7-5-16)24(36)19-3-2-18(13-20(19)29)37-25(26, 27)28/h2-3, 12-16H, 4-11, 29H2, 1H3 SMILES Code: O=C(C1=CC=C(OC(F)(F)F)C=C1N)N2CCC(C3=C4C(C=C(N5CCN(C)CC5)C=N4)=NC=N3)CC2

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Amount: 5 mg

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Delivery expected until 11/6/2025

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