Fulacimstat

InvivoChem Cat #:V4220CAS #:1488354-15-9 Purity >=98%

Description: Fulacimstat (also known as BAY1142524) is a novel, potent and orally bioavailable chymase inhibitor with IC50s of 4, 3 nM for human and hamster chymase enzyme, respectively. Fulacimstat has the potential to be used as an antifibrotic drug candidate and is currently being developed as a first-in-class treatment for left-ventricular dysfunction after myocardial infarction.

Description:

References: Circulation. 2018; 136:A13624.; Clin Pharmacol Drug Dev. 2018 Jun 7.

References:

-20C for 3 years in powder form

Synonym: BAY1142524; BAY-1142524; BAY 1142524
IUPAC/Chemical Name: 1-(3-methyl-2-oxo-2, 3-dihydro-1, 3-benzoxazol-6-yl)- 2, 4-dioxo-3-[(1R)-4-(trifluoromethyl)-2, 3-dihydro-1H-inden- 1-yl]-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylic acid
InChi Key: JDARDSVOVYVQST-MRXNPFEDSA-N
InChi Code: InChI=1S/C23H16F3N3O6/c1-27-17-7-5-11(9-18(17)35-22(27)34)28-10-14(20(31)32)19(30)29(21(28)33)16-8-6-12-13(16)3-2-4-15(12)23(24, 25)26/h2-5, 7, 9-10, 16H, 6, 8H2, 1H3, (H, 31, 32)/t16-/m1/s1
SMILES Code: O=C(C1=CN(C2=CC=C3N(C)C(OC3=C2)=O)C(N([CH]4CCC5=C4C=CC=C5C(F)(F)F)C1=O)=O)O