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MK-886 (L-663536)

MK-886 (L-663536)

Item no.	V4328-5mg
Manufacturer	InvivoChem LLC
CASRN	118414-82-7
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	118414-82-7
Available
Description	InvivoChem Cat #:V4328CAS #:118414-82-7 Purity >=98% Description: MK886 ( also known as L 663536) is a novel and potent 5-lipoxygenase-activating protein inhibitor and a leukotriene biosynthesis inhibitor (IC50=2.5 nM). MK-886 acts by blocking the 5-lipoxygenase activating protein (FLAP), thus inhibiting 5-lipoxygenase (5-LOX), and may help in treating atherosclerosis. MK-886 inhibits cyclooxygenase-1 activity and suppresses platelet aggregation. MK-886 induces changes in cell cycle and increases apoptosis after photodynamic therapy with hypericin. MK-886 enhances tumour necrosis factor-alpha-induced differentiation and apoptosis. References: Biochem J. 2001 Jun 15; 356(Pt 3):899-906; Nature, 1990 Jan 18, 343(6255):282-4. Related CAS #: 118414-82-7 (free acid) 118427-55-7 (sodium) 1049737-88-3 (sodium hydrate)
	Name: MK-886 CAS#: 118414-82-7 Chemical Formula: C27H34ClNO2S Exact Mass: 471.19988 Molecular Weight: 472.084 Elemental Analysis: C, 68.69; H, 7.26; Cl, 7.51; N, 2.97; O, 6.78; S, 6.79
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: L-663, 536; L663, 536; L 663, 536; MK-886; MK886; MK 886; L-663536; L663536; L 663536. Chemical Name: 3-[3-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-yl-indol-2-yl]-2, 2 -dimethyl-propanoic acid InChi Key: VFMGWQLOCZBFCK-UHFFFAOYSA-N InChi Code: InChI=1S/C27H34ClNO2S/c1-6-7-14-32-25-22-15-20(18(2)3)10-13-23(22)29(17-19-8-11-21(28)12-9-19)24(25)16-27(4, 5)26(30)31/h8-13, 15, 18H, 6-7, 14, 16-17H2, 1-5H3, (H, 30, 31) SMILES Code: O=C(O)C(C)(C)CC(N1CC2=CC=C(Cl)C=C2)=C(SCCCC)C3=C1C=CC(C(C)C)=C3

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Amount: 5 mg

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