telithromycin

InvivoChem Cat #:V4413CAS #:191114-48-4Purity >=98%

Description: Telithromycin (also known as HMR-3647 and RU-66647) is the first ketolide antibiotic to enter clinical use and is sold under the brand name of Ketek. It is used to treat community acquired pneumonia of mild to moderate severity. After significant safety concerns, the US Food and Drug Administration sharply curtailed the approved uses of the drug in early 2007. Telithromycin is a semi-synthetic erythromycin derivative. It is created by substituting a ketogroup for the cladinose sugar and adding a carbamate ring in the lactone ring. An alkyl-aryl moiety is attached to this carbamate ring. Furthermore, the carbon at position 6 has been methylated, as is the case in clarithromycin, to achieve better acid-stability.

References: http://en.wikipedia.org/wiki/Telithromycin

-20C for 3 years in powder form

Synonym: HMR-3647; HMR 3647; HMR3647; RU-66647; RU 66647; RU66647
IUPAC/Chemical Name: (3aS, 4R, 7R, 9R, 10R, 11R, 13R, 15R, 15aR)-10-(((2S, 3R, 4S, 6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-11-methoxy-3a, 7, 9, 11, 13, 15-hexamethyl-1-(4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)butyl)octahydro-2H-[1]oxacyclotetradecino[4, 3-d]oxazole-2, 6, 8, 14(1H, 7H, 9H)-tetraone
InChi Key: LJVAJPDWBABPEJ-PNUFFHFMSA-N
InChi Code: InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7, 54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17, 22-29, 32-33, 36-38, 40, 51H, 12-14, 18-21H2, 1-11H3/t25-, 26-, 27+, 28+, 29-, 32+, 33-, 36-, 37-, 38-, 40+, 42-, 43-/m1/s1
SMILES Code: O=C([CH](C)C[C](C)(OC)[CH](O[CH]1O[CH](C)C[CH](N(C)C)[CH]1O)[CH](C)C([CH](C)C(O[CH](CC)[C]2(C)O3)=O)=O)[CH](C)[C]2([H])N(CCCCN4C=C(C5=CC=CN=C5)N=C4)C3=O