ML349

Item no.	V4495-5mg
Manufacturer	InvivoChem LLC
CASRN	890819-86-0
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	890819-86-0
Available
Description	InvivoChem Cat #:V4495CAS #:890819-86-0Purity >=98% Description: ML349 is a novel, potent, reversible, highly selective and specific acyl protein thioesterase 2 (APT-2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM. Although ML349 is highly selective within the serine hydrolase enzyme family, it could still interact with other cellular targets. In human cell lysates, biotinylated-ML349 enriches a recurring set of proteins, including metabolite kinases and flavin-dependent oxidoreductases that are potentially enhanced by avidity-driven multimeric interactions. ML349 achieves target engagement and hydrolase selectivity in living mice. References: Oncotarget. 2016 Feb 9; 7(6):7297-306.; ACS Chem Biol. 2016 Dec 16; 11(12):3374-3382.
	Name: ML349 CAS#: 890819-86-0 Chemical Formula: C23H24N2O4S2 Exact Mass: 456.1177 Molecular Weight: 456.575 Elemental Analysis: C, 60.51; H, 5.30; N, 6.14; O, 14.02; S, 14.04
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: ML349; ML-349; ML 349. IUPAC/Chemical Name: (5, 5-dioxido-3a, 9b-dihydro-4H-thieno[3, 2-c]thiochromen-2-yl)(4-(4-methoxyphenyl)piperazin-1-yl)methanone InChi Key: JIFSCAIWCCQTRF-UHFFFAOYSA-N InChi Code: InChI=1S/C23H24N2O4S2/c1-29-18-8-6-17(7-9-18)24-10-12-25(13-11-24)23(26)20-14-16-15-31(27, 28)21-5-3-2-4-19(21)22(16)30-20/h2-9, 14, 16, 22H, 10-13, 15H2, 1H3 SMILES Code: COC1=CC=C(N2CCN(C(C3=CC4C(C(C=CC=C5)=C5S(C4)(=O)=O)S3)=O)CC2)C=C1

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Amount: 5 mg

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