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Tafamidis

Tafamidis

Item no.	V4862-10mg
Manufacturer	InvivoChem LLC
CASRN	594839-88-0
Amount	10 mg
Quantity options	100 mg 1 g 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	594839-88-0
Available
Description	InvivoChem Cat #:V4862CAS #:594839-88-0 (free)Purity >=98% Description: Tafamidis (also known as Fx-1006 or PF-06291826), a potent and selective transthyretin (TTR) stabilizer, is a drug for the amelioration of transthyretin-related hereditary amyloidosis (also familial amyloid polyneuropathy, or FAP), a rare but deadly neurodegenerative disease. It shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 uM. Tafamidis inhibits amyloidogenesis. The drug was approved by the European Medicines Agency in November 2011 and by the Japanese Pharmaceuticals and Medical Devices Agency in September 2013. Tafamidis functions by kinetic stabilization of the correctly folded tetrameric form of the transthyretin (TTR) protein. References: Proc Natl Acad Sci U S A, 2012. 109(24): p. 9629-34. Related CAS: 951395-08-7 (meglumine salt)
	Name: Tafamidis CAS#: 594839-88-0 (free acid) Chemical Formula: C14H7Cl2NO3 Exact Mass: 306.9803 Molecular Weight: 308.114 Elemental Analysis: C, 54.58; H, 2.29; Cl, 23.01; N, 4.55; O, 15.58
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: Fx-1006, Fx1006, Fx 1006, Fx-1006A; PF-06291826; PF06291826; PF 06291826; Tafamidis; Vyndaqel IUPAC/Chemical Name: 2-(3, 5-dichlorophenyl)benzo[d]oxazole-6-carboxylic acid InChi Key: TXEIIPDJKFWEEC-UHFFFAOYSA-N InChi Code: InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H, (H, 18, 19) SMILES Code: O=C(C1=CC=C2N=C(C3=CC(Cl)=CC(Cl)=C3)OC2=C1)O

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Amount: 10 mg

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Delivery expected until 9/4/2025

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