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adomeglivant

adomeglivant

Item no.	V4891-10mg
Manufacturer	InvivoChem LLC
CASRN	1488363-78-5
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1488363-78-5
Available
Description	InvivoChem Cat #:V4891CAS #:1488363-78-5Purity >=98% Description: Adomeglivant (also known as LY-2409021) is a novel, potent and selective glucagon receptor antagonist that is being investigated in clinical trial for type 2 diabetes mellitus. Adomeglivant (LY2409021) lowers blood glucose in healthy people and in those with type 2 diabetes. Blockade of glucagon signalling in patients with type 2 diabetes is well tolerated and results in substantial reduction of fasting and postprandial glucose with minimal hypoglycaemia, but with reversible increases in aminotransferases. Inhibition of glucagon signalling by LY2409021 is a promising potential treatment for patients with type 2 diabetes and should be evaluated in longer clinical trials to better evaluate benefits and risks. References: Org Lett. 2015 May 1; 17(9):2186-9.; Diabetes Care. 2016 Jul; 39(7):1241-9.
	Name: Adomeglivant CAS#: 1488363-78-5 Chemical Formula: C32H36F3NO4 Exact Mass: 555.2596 Molecular Weight: 555.64 Elemental Analysis: C, 69.17; H, 6.53; F, 10.26; N, 2.52; O, 11.52
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: LY2409021; LY-2409021; LY 2409021 IUPAC/Chemical Name: 3-(4-{(1S)-1-[(4'-tert-butyl-2, 6-dimethylbiphenyl-4-yl)oxy]-4, 4, 4-trifluorobutyl}benzamido)propanoic acid InChi Key: FASLTMSUPQDLIB-MHZLTWQESA-N InChi Code: InChI=1S/C32H36F3NO4/c1-20-18-26(19-21(2)29(20)23-10-12-25(13-11-23)31(3, 4)5)40-27(14-16-32(33, 34)35)22-6-8-24(9-7-22)30(39)36-17-15-28(37)38/h6-13, 18-19, 27H, 14-17H2, 1-5H3, (H, 36, 39)(H, 37, 38)/t27-/m0/s1 SMILES Code: O=C(O)CCNC(C1=CC=C([CH](OC2=CC(C)=C(C3=CC=C(C(C)(C)C)C=C3)C(C)=C2)CCC(F)(F)F)C=C1)=O

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