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Description: Burixafor HBr, the hydrobromide salt of Burixafor (also known as TG-0054 hydrobromide), is a novel, potent and orally bioavailable antagonist of CXCR4 (CXC chemokine receptor 4). It is a well water soluble anti-angiogenic drug that is of potential value in treating choroid neovascularization. Burixafor, also known as TG-0054, is an orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with receptor binding and hematopoietic stem cell-mobilization activities. Burixafor binds to the chemokine receptor CXCR4, thereby preventing the binding of stromal derived factor-1 (SDF-1 or CXCL12) to the CXCR4 receptor and subsequent receptor activation; this may the mobilization of hematopoietic stem and progenitor cells from the bone marrow into blood.
References: Drug Deliv Transl Res. 2011 Feb; 1(1):76-90.; Cell Transplant. 2015; 24(7):1313-28.
Related CAS #: 1191450-19-7 (HBr); 1191448-17-5 (free acid)
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