Comparison

burixafor-hbr

Item no. V5009-25mg
Manufacturer InvivoChem LLC
CASRN 1191450-19-7 (HBr)
Amount 25mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Available
Description
InvivoChem Cat #:V5009CAS #:1191450-19-7 (HBr)Purity >=98%

Description: Burixafor HBr, the hydrobromide salt of Burixafor (also known as TG-0054 hydrobromide), is a novel, potent and orally bioavailable antagonist of CXCR4 (CXC chemokine receptor 4). It is a well water soluble anti-angiogenic drug that is of potential value in treating choroid neovascularization. Burixafor, also known as TG-0054, is an orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with receptor binding and hematopoietic stem cell-mobilization activities. Burixafor binds to the chemokine receptor CXCR4, thereby preventing the binding of stromal derived factor-1 (SDF-1 or CXCL12) to the CXCR4 receptor and subsequent receptor activation; this may the mobilization of hematopoietic stem and progenitor cells from the bone marrow into blood.

References: Drug Deliv Transl Res. 2011 Feb; 1(1):76-90.; Cell Transplant. 2015; 24(7):1313-28.

Related CAS #: 1191450-19-7 (HBr); 1191448-17-5 (free acid)

Burixafor HBr

Name: Burixafor HBr
CAS#: 1191450-19-7 (HBr)
Chemical Formula: C27H60Br3N8O6P
Exact Mass: 566.3822
Molecular Weight: 863.51
Elemental Analysis: C, 37.56; H, 7.00; Br, 27.76; N, 12.98; O, 11.12; P, 3.59
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Technical Information
Synonym: TG-0054; TG 0054; TG0054; Burixafor; Burixafor HBr; Burixafor HBr hydrate; Burixafor trihydrobromide trihydrate
IUPAC/Chemical Name: (2-(4-(6-amino-2-((((1r, 4r)-4-(((3-(cyclohexylamino)propyl)amino)methyl)cyclohexyl)methyl)amino)pyrimidin-4-yl)piperazin-1-yl)ethyl)phosphonic acid trihydrobromide trihydrate
InChi Key: FAIXPLRLFBALHM-MCXZQIONSA-N, VXFATXVZERUULG-YCGNAKKISA-N (3HBr 3H2O).
InChi Code: InChI=1S/C27H51N8O3P.3BrH.3H2O/c28-25-19-26(35-15-13-34(14-16-35)17-18-39(36, 37)38)33-27(32-25)31-21-23-9-7-22(8-10-23)20-29-11-4-12-30-24-5-2-1-3-6-24; ; ; ; ; ; /h19, 22-24, 29-30H, 1-18, 20-21H2, (H2, 36, 37, 38)(H3, 28, 31, 32, 33); 3*1H; 3*1H2/t22-, 23-; ; ; ; ; ;
SMILES Code: NC1=CC(N2CCN(CCP(O)(O)=O)CC2)=NC(NC[CH]3CC[CH](CNCCCNC4CCCCC4)CC3)=N1.[H]Br.[H]Br.[H]Br.[H]O[H].[H]O[H].[H]O[H]

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 25mg
Available: In stock
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