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Description: Lomustine (also known as CCNU) is a nitrosourea anticancer drug that belongs to the class of DNA alkylating agents. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and thus able to cross the blood-brain barrier.
References: J Neurosurg. 2015 Mar; 122(3):547-56.
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