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Description: Pindolol (known also as LB-46), a nonselective beta-blocker with partial beta-adrenergic receptor agonist activity, is an aryloxypropanolamine derivative with antihypertensive property. Pindolol competitively binds to beta-adrenergic receptors, resulting in a decrease in beta-adrenergic activities, i.e., vasodilation, and negative chronotropic and inotropic effects. In addition, this agent blocks serotonin (5-HT) 1A receptors, thereby increasing the available serotonin in the brain. Increased serotonin levels augment the antidepressant action of selective serotonin reuptake inhibitors and monoamine oxidase inhibitors.
References: Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec; 368(6):496-503. Epub 2003 Nov 8. PMID: 14608456
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