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Description: GSK2983559 active metabolite, formerly known as RIPK2-IN-1, is an active metabolite of GSK2983559 which is a potent and selective inhibitor of receptor interacting protein-2 (RIP2) kinase.
References: PCT Int. Appl. (2014), WO 2014043446 A1 20140320; Goncharov T, Hedayati S, Mulvihill MM, Izrael-Tomasevic A, Zobel K, Jeet S, Fedorova AV, Eidenschenk C, deVoss J, Yu K, Shaw AS, Kirkpatrick DS, Fairbrother WJ, Deshayes K, Vucic D. Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling. Mol Cell. 2018 Feb 15; 69(4):551-565.e7.
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