Canine IL-2 ELISA Kit

Interleukin 2 (IL-2), also known as T cell growth factor (TCGF), is a member of the common gamma chain (I³c) cytokine family. The 153 amino acid (aa) human IL-2 precursor contains a 20 aa signal sequence and a 133 aa mature region with one O-linked glycosylation site at Thr3, plus three cysteines, two of which form an intrachain disulfide bond that is essential for IL-2 bioactivity. Human IL-2 shares approximately 60% sequence identity with mouse IL-2, and is functional on mouse IL-2 responsive cells. IL-2 is expressed and secreted on I³I´T cells, activated conventional CD4+ and CD8+ T cells, neurons, microglia, and hematopoietic stem cells in humans. IL-2 first binds to IL-2 receptorI+/- (IL-2RI+/-)/ CD25 in the binary receptor complex then recruits IL-2Rbeta/CD122 and IL-2RI³/CD132 to trigger a variety of biological processes. IL-2 plays a key role in the development, maintenance and function of regulatory T cells and in promoting the development of activated CD8+ T cells into memory cells.

7.81-500pg/mL

Cell culture supernatants, serum and plasma.

Store at 2 - 8 C. Keep reconstituted standard and detection Ab at -20 C