Human uPAR ELISA Kit

The Urokinase receptor, also known as uPA receptor, monocyte activation antigen Mo3, uPAR or CD87, is a highly glycosylated integral membrane protein linked to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor and a receptor for urokinase-type plasminogen activator (uPA). The mature uPAR is a 283 amino acid (aa) protein derived from the full-length 335 aa uPAR precursor after removing the 22 aa signal peptide and a 30 aa fragment from the C-terminus during addition of the GPI anchor. uPAR, uPA and plasminogen activator inhibitor-1 (PAI-1) form a heterotrimetic complex that has exhibited diverse functions in regulation of cell attachment, migration, proliferation and differentiation, by both proteolytic and nonproteolytic mechanisms. There is a negative-feedback regulation by which uPAR mediates proteolysis-independent signal transduction of uPA and, in turn, uPA cleaves uPAR into an inactive form. uPAR has been involved in various non-proteolytic processes related to cancer, cell migration, cell cycle regulation, and cell adhesion.

62.5--4000pg/mL

Store at 2 - 8 C