Mouse IL-17 ELISA Kit

Interleukin 17 (IL-17), also known as IL-17A or Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8), is a glycosylated polypeptide belonging to the IL-17 family which consists of IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F, in addition to IL-17A. Mouse IL-17 is a 158 amino acid (aa) precursor containing a 25 aa signal peptide and a 133 aa mature segment. Natural occurring mouse IL-17A exists in a disulfide-linked homodimer and a covalent heterodimer with IL-17F. Most secreted IL-17 is in the form of the IL-17A/IL-17F heterodimer, however, the activity of IL-17/IL-17A homodimer is more potent than the heterodimer. Mature mouse IL-17A is 61% and 89% aa identical to human and rat IL-17A, respectively. Notably, human IL-17 is active on both mouse and rat cells. IL-17 are expressed in many different cell types such as CD4+ Th17 T cells, Paneth cells, GR1+CD11b+ myeloid suppressor cells, CD27-I³I´ T cells, CD1+NK1.1-iNKT cells, and CD3-CD4+ LTi-like cells. Mouse IL-17 receptor is a heterodimeric complex composed of IL-17RA and IL-17RC. Both IL-17RA and IL-17RC are type I transmembrane glycoprotein and are required for IL-17 and IL-17/IL-17F activity. IL-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines and participates in the recruitment and survival of neutrophils.

15.6--1000pg/mL

serum, plasma or cell culture supernatant

Store at 2 - 8 C. Keep reconstituted standard and detection Ab at -20 C